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Functional neuroimaging of attention-deficit/hyperactivity disorder: a review and suggested future directions.

Bush G, Valera EM, Seidman LJ

Psychiatric Neuroscience Program and Department of Psychiatry, Harvard Medical School and Massachusettes General Hospital, Boston, Massachusetts, USA. geo@nmr.mgh.harvard.edu

Over the past few decades, functional neuroimaging techniques have begun to provide unprecedented windows on the neurobiology of attention-deficit/hyperactivity disorder (ADHD) and the neural effects of medications used to treat the disorder. Convergent data from neuroimaging, neuropsychological, genetics, and neurochemical studies have implicated dysfunction of fronto-striatal structures (lateral prefrontal cortex, dorsal anterior cingulate cortex, caudate, and putamen) as likely contributing to the pathophysiology of ADHD. This review 1) provides an overview of the main imaging techniques being used to study ADHD; 2) discusses their relative strengths and weaknesses, highlighting how they can complement one another; 3) shows how the functional imaging literature, which has built on the structural imaging data, is now being used to test focused hypotheses regarding the neurobiological substrate of ADHD; and 4) suggests guidelines for improving future functional imaging studies. Although at present there are no accepted uses for functional imaging in diagnosing ADHD, this article mentions possible future clinical uses of imaging in ADHD.

Published 13 June 2005 in Biol Psychiatry, 57(11): 1273-84.
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