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Association analysis of serotonin transporter promoter gene polymorphism with ADHD and related symptomatology.

Zhao AL, Su LY, Zhang YH, Tang BS, Luo XR, Huang CX, Su QR

Departmemt of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha Hunan, People's Republic of China.

Attention deficit hyperactivity disorder (ADHD) is one of the most common childhood behavioral disorders. Genetic factors contribute to the underlying liability to develop attention deficit hyperactivity disorder. Several investigations have reported associations between ADHD and serotonin transporter promoter polymorphisms, but the results have been inconsistent. The present study did not find significant association between ADHD and serotonin transporter promoter polymorphisms, but did find an effect of serotonin transporter promoter polymorphisms on some ADHD symptomatology. Patients homozygous for the short allele showed more Withdrawn or Somatic complaint scores than subjects with the long allele.

Published 25 July 2005 in Int J Neurosci, 115(8): 1183-91.
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