CREM mutations and ADHD symptoms.
Lahti TA, Partonen T
National Public Health Institute, Department of Mental Health and Alcohol Research, Mannerheimintie 166, FI-00300 Helsinki, Finland.
CREM mutant mice have behaviors similar to symptoms seen in ADHD such as the increased level of physical activity as well as altered emotional and stress responses. Our results demonstrate that all the four participants with ADHD had elevated levels of nocturnal melatonin in urine samples before starting the methylphenidate treatment. We hypothesize that abnormalities in CREM protein functions or mutations in the CREM gene may be underlying at least some of the symptoms in patients with ADHD.
Published 4 March 2009 in Med Hypotheses, 72(5): 544-5.
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